The need for good quality sleep is essential for promoting proper healing and maintaining healthy bodily function. Pain, which may be associated with injury and acute and chronic disorders often compromises the body’s ability to heal by leading to sleep disorders. It has been found that the body is regenerative process occurs at night because 70% of growth hormones are produced while sleeping.

Hormones are chemical substances secreted into the blood by the endocrine glands and carried by blood and tissue fluids to the cells they act upon. Different classes of hormones (such as steroid, peptide or protein and amine) act on the target tissue by different mechanisms and can alter the function of the target tissue.

Peptide and protein hormones (insulin) stimulate the intracellular enzyme activity by interacting with receptor sites on the cell surface. Protein is needed to meet the need for tissue repair and resistance to infection. Protein helps to replace losses resulting from immobility. Steroid hormones (such as glucocorticoids and hydrocorticoids) are important factors of glucose metabolism. Increased secretion of these hormones can result in elevated blood glucose levels.

The lack of sleep and hormonal instability is not unusual in patients with chronic wounds.  Sleep deprivation can diminish the body’s ability to secrete and respond to the hormone insulin which helps regulate blood sugar. Athletes can have compromised blood sugar and insulin levels, and further problems with sleeping can lead to poor health and complications.

Growth factors, including basic fibroblast growth factor (bFGF), insulin-like growth factor-1 (IGF-1), and nerve growth factor (NGF), can improve muscle regeneration.

The use of the ReviStim DC stimulator has the effect of transforming growth factor-β1 (TGF-β1) can prevent fibrosis and improve muscle healing, resulting in nearly complete recovery.

It is noteworthy to mention that the body naturally minimizes blood flow to the extremities while sleeping to maintain body trunk core temperature and functions. This in turn, can further the process of pain while sleeping. Athletes already suffering from poor circulatory problems in their muscle and vessels may in fact benefit from nighttime therapy that promotes microcirculation.